With the world on the brink of war, and its toxic effects not yet well described, the clinical effects of methamphetamine were thought to be ideal for the soldier in combat: increased alertness and aggression, plus decreased hunger and need to sleep. 4– 6 Far from an OTC drug today, the FDA has characterized methamphetamine as a schedule II drug which can only be prescribed for ADHD, extreme obesity, or to treat narcolepsy. 2, 3 Eventually a synthetic version would find its way to the consumer market as an over-the-counter (OTC) nasal decongestant and as a brochodilator. In 1893 methamphetamine was synthesized from ephedrine (derived from the plant Ephedra sinica) by Nagai Nagayoshi. 1 Based on the attractiveness of methamphetamine to both users and its manufacturers, it is only surprising that the current outbreak of methamphetamine abuse in the US took so long to reach epidemic proportions. This is in contrast to cocaine which is only commercially grown in South America, must be extracted from the plant, must be converted to its free base form, must be shipped overseas (escaping DEA detection), and then must be distributed, typically through gangs, to clients on the street. Methamphetamine can be produced from a wide variety of starting materials and methods. The current epidemic of methamphetamine abuse in the US is not surprising.
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